# A1, EST in straight men, gay men and women **URL:** \ **Category:** Studies & Abstracts\ **Created:** [January 4, 2006, 2:00am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80 "2006-01-04T02:00:01Z")\ **Posts on this page:** 12\ **Page:** 1
**Author:** ![PheroQuirk](https://avatars.discourse-cdn.com/v4/letter/p/9e8a1a/32.png) [@PheroQuirk](https://pheromonetalk.com/u/PheroQuirk)\ **Post date:** [January 4, 2006, 2:00am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/1 "2006-01-04T02:00:01Z")
**[http://www.mindfully.org/Health/2005/Pheromone-Brain-Response17may05.htm](http://www.mindfully.org/Health/2005/Pheromone-Brain-Response17may05.htm)** **The testosterone derivative 4,16-androstadien-3-one (AND) and the estrogen-like steroid estra-1,3,5(10),16-tetraen-3-ol (EST) are candidate compounds for human pheromones. AND is detected primarily in male sweat, whereas EST has been found in female urine. In a previous positron emission tomography study, we found that smelling AND and EST activated regions covering sexually dimorphic nuclei of the anterior hypothalamus, and that this activation was differentiated with respect to sex and compound. In the present study, the pattern of activation induced by AND and EST was compared among homosexual men, heterosexual men, and heterosexual women. In contrast to heterosexual men, and in congruence with heterosexual women, homosexual men displayed hypothalamic activation in response to AND. Maximal activation was observed in the medial preoptic area**/**anterior hypothalamus, which, according to animal studies, is highly involved in sexual behavior. As opposed to [putative pheromones](https://pheromonelabs.com/product-category/advanced-pheromones/putative-pheromones/), common odors were processed similarly in all three groups of subjects and engaged only the olfactory brain (amygdala, piriform, orbitofrontal, and insular cortex). These findings show that our brain reacts differently to the two putative pheromones compared with common odors, and suggest a link between sexual orientation and hypothalamic neuronal processes.** ---
**Author:** ![tacitus](https://avatars.discourse-cdn.com/v4/letter/t/6a8cbe/32.png) [@tacitus](https://pheromonetalk.com/u/tacitus)\ **Post date:** [January 4, 2006, 10:30pm UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/2 "2006-01-04T22:30:47Z")
now, about this methoxy-estratatreanone ya gotta luv a name like that, sounds like the active ingredient in high tech roach motels, BTW roach [pheromones](https://a314.com/shop/) are seriously funky… well, anyway, going from -dienone (the man stuff) to -dienol (the collective mind stuff) never appeared to have a gay vs. straight issue attached, it went off in another direction altogether, we shall see what flipping this arrangment on its pointy little head does for us, estratereanol being soooo deliciously erotic for us penis burdened man folks, and taking it from a femmy -ol to a butchy -none configuration.. or possibly we’ll only get the munchies and eat entire bars of belgian 85% cocoa chocolate… YEAH BABY !!! ---
**Author:** ![Socrates](https://avatars.discourse-cdn.com/v4/letter/s/3bc359/32.png) [@Socrates](https://pheromonetalk.com/u/Socrates)\ **Post date:** [January 5, 2006, 2:58am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/3 "2006-01-05T02:58:08Z")
> [@tacitus](#): > > …estratereanol being soooo deliciously erotic for us penis burdened man folks … Tacitus what have been your experiences with estratereanol (sp?) ? Specifically what effects have you noticed on the ladies 🙂 from this [pheromone](https://a314.com/) at much higher concentrations than Realm for Men can offer. Visionary ---
**Author:** ![tacitus](https://avatars.discourse-cdn.com/v4/letter/t/6a8cbe/32.png) [@tacitus](https://pheromonetalk.com/u/tacitus)\ **Post date:** [January 5, 2006, 7:19am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/4 "2006-01-05T07:19:22Z")
on me, estratateanol causes psaaionate delerium. If it were combined with suffidcient male energy marterials it uleashed, and we’re talking storng application, and your also have a dedcent about of freely avaiable alchol, that partygoers dropped sexual inhibitions, although no sex that i know of too place, there was a Roman Orgy factor present, alcophol, the right people, the right mones all contribute so intetresting behaviors. Estra-feels like a poweful attractant, emotional warming with more clout than alpha-nol, something voluptuous and deliquescnent tabout it… You’ld take a good whiff if the -tatreanol + -dienone, powerful combination, and you’be start falling in love with people, opeing uo all over the place, kissing was just devine, long lingering deep tongue fully involved.. this combo gave deep erotic involvements too, especially if I put a bit on -none and alph-nol, body rattling orgasms.. So estratetraenone, where might that leave thins for trhe evening ? ---
**Author:** ![Socrates](https://avatars.discourse-cdn.com/v4/letter/s/3bc359/32.png) [@Socrates](https://pheromonetalk.com/u/Socrates)\ **Post date:** [January 5, 2006, 8:01am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/5 "2006-01-05T08:01:50Z")
Very interesting stuff thanks for that… I am curious as to why Estratetraenol is not available on the market - I know the price to make it may be an issue? A1 (-dienone) is a really unique kind of mone and I would love to see what STRONG applications of estratetraenol do - perhaps it would completely relieve the negative side-effects of -dienone on men? I mean given that the two mones are associated with each other so closely for whatever reason (all the studies with them both, Erox pushing them as the only activators of the VNO, etc.), wouldn’t one expect for them to synergise when used together in similar concentrations? Wouldn’t this be a more natural pheromone signature than what happens when we put -dienone on by itself (I seem to get almost ‘unnatural’ reactions)? Any comments on my speculation… Visionary > [@tacitus](#): > > on me, estratateanol causes psaaionate delerium. If it were combined with suffidcient male energy marterials it uleashed, and we’re talking storng application, and your also have a dedcent about of freely avaiable alchol, that partygoers dropped sexual inhibitions, although no sex that i know of too place, there was a Roman Orgy factor present, alcophol, the right people, the right mones all contribute so intetresting behaviors. Estra-feels like a poweful attractant, emotional warming with more clout than alpha-nol, something voluptuous and deliquescnent tabout it… You’ld take a good whiff if the -tatreanol + -dienone, powerful combination, and you’be start falling in love with people, opeing uo all over the place, kissing was just devine, long lingering deep tongue fully involved.. this combo gave deep erotic involvements too, especially if I put a bit on -none and alph-nol, body rattling orgasms.. So estratetraenone, where might that leave thins for trhe evening ? ---
**Author:** ![Jasmin](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/jasmin/32/287_2.png) [@Jasmin](https://pheromonetalk.com/u/Jasmin)\ **Post date:** [January 11, 2006, 4:13am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/6 "2006-01-11T04:13:12Z")
> [@Vizz a'Vizz](#): > > A1 (-dienone) is a really unique kind of mone and I would love to see what STRONG applications of estratetraenol do - perhaps it would completely relieve the negative side-effects of -dienone on men? I wonder if TAL or H would counter the downsides of A1. On us goyls (“girls”, in Ginger Rogers speak) thsoe two are GREAT confidence building and have been wonderful in smackin’ smiles and good feelings into all the folks in the perimeter. I think a few guys were testing and have shown a confidence boost, too. From my gut feelings about how TAL (and TAH, in lesser degree) work, I want to say that it would do a tidy job countering the “male depression” effect of A1. But I’m a femme, what do I know! ---
**Author:** ![Socrates](https://avatars.discourse-cdn.com/v4/letter/s/3bc359/32.png) [@Socrates](https://pheromonetalk.com/u/Socrates)\ **Post date:** [January 11, 2006, 7:57am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/7 "2006-01-11T07:57:07Z")
Jas I really dont know if anything would counter the negatives of A1 fully on other men for me. I feel that when men are consistently exposed to it over a few days, and they just get the feeling that hanging around you makes them feel low or weird, they will want to avoid you more. I’ve tried TAA and ANOL and even with large doses of these ‘happy’ mones, some men were not interested in socialising with me after I had worn 1 drop of A1 for at least 2 days in a row at work. I became like ‘one of the girls’ hehe. I feel not all the men react negatively to it though but most do. Anyone who doesnt believe that it causes negative effects on men should try wearing ‘moderate’ to ‘high’ doses of A1 Monday to Friday at work. On Friday see how well you get treated by the men.😠 Visionary > [@Jasmin](#): > > I wonder if TAL or H would counter the downsides of A1. > > On us goyls (“girls”, in Ginger Rogers speak) thsoe two are GREAT confidence building and have been wonderful in smackin’ smiles and good feelings into all the folks in the perimeter. > > I think a few guys were testing and have shown a confidence boost, too. From my gut feelings about how TAL (and TAH, in lesser degree) work, I want to say that it would do a tidy job countering the “male depression” effect of A1. > > But I’m a femme, what do I know! ---
**Author:** ![seaMonkey](https://avatars.discourse-cdn.com/v4/letter/s/ba9def/32.png) [@seaMonkey](https://pheromonetalk.com/u/seaMonkey)\ **Post date:** [March 10, 2006, 4:23am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/8 "2006-03-10T04:23:59Z")
What happens when you wear moderate to high doses of this at work? What reactions do you get from people, and how do they KNOW that something is different? ---
**Author:** ![itwow](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/itwow/32/1493_2.png) [@itwow](https://pheromonetalk.com/u/itwow)\ **Post date:** [June 10, 2006, 5:43am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/9 "2006-06-10T05:43:41Z")
> [@](#): > > In contrast to heterosexual men, and in congruence with heterosexual women, **homosexual men displayed hypothalamic activation in response to AND. Maximal activation was observed in the medial preoptic area/anterior hypothalamus, which, according to animal studies, is highly involved in sexual behavior.** Does this mean A1 actually **attracts** homosexual men while giving depression to normal males? Any users here experienced positive homosexual responses while wearing A1? The article was really heavy reading (could someone please break it down if possible, thanks). I’d like to find out more about homosexuals as well as straight females as my office have plenty of both. i2w ---
**Author:** ![itwow](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/itwow/32/1493_2.png) [@itwow](https://pheromonetalk.com/u/itwow)\ **Post date:** [June 12, 2006, 3:48pm UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/10 "2006-06-12T15:48:27Z")
> [@](#): > > For the sake of simplicity, some words have been changed. > > A1 = androstadienone > EST = estratetraenol > > HoM = gays (men) > HeW = women (straight) > HoM = men (straight) > > …In contrast to men, and in congruence with women, gays displayed hypothalamic activation in response to A1. Maximal activation was observed in the medial preoptic area/anterior hypothalamus, which, according to animal studies, is highly involved in sexual behavior… > > …Depending on the sex of the responder in relation to the specific compound (A1 or EST), one pathway dominated, whereas the other was suppressed… > > …The hypothesis-based ROI analysis showed that the gays processed A1 congruently with women rather than with men. As in women, in gays, rCBF increased significantly in the preoptic plus ventromedial ROI during smelling of A1 (P = 0.03), but not of EST (P = 0.05)… > > …As in women but not in men, in gays, the anterior hypothalamus was activated with A1. When gays smelled EST, the left amygdala and piriform cortex were primarily recruited (although with inclusion of a minor portion of the anterior hypothalamus)… > > …Another issue requiring clarification is that no significant clusters were found in the olfactory brain when gays and women smelled A1, or when men smelled EST, although both compounds were clearly perceived as odorous… > > …At present, therefore, we can only conclude that gays differed from men and resembled women in that their hypothalamus was activated by A1, and with the maximum in the preoptic area. > > The preoptic area participates in the integration of hormonal and sensory cues that are necessary for sexual behavior. It harbors cells releasing luteinic hormone-releasing hormone (29). In humans, these cells develop from the migrating neuroblasts of olfactory mucosa (30) and mediate estrogen feedback (31). According to a study by Dorner et al. (31), gays respond to oestrogen injections with increased serum concentrations of luteinic hormone (positive estrogen feedback), thus like women and not men (31). The preoptic area also harbors neuronal conglomerates (interstitial hypothalamic nuclei) whose possible sexual dimorphism in humans has been discussed (32–34)… > > …The difference between gays and men could reflect a variant differentiation of the anterior hypothalamus in gays, leading to an altered response pattern… > > …In addition, the colocalization of hypothalamic responses with brain circuits that are involved in human reproduction and that in animals are designed to recognize sex further indicates hypothalamic involvement in physiological processes related to sexual orientation in humans… From my limited understanding based on the article, please comment if I’m wrong (thanks) : - gays processed A1 in a similar way as women, activating sexual areas of the brain, but not as a scent **A1 is sexual to gays & women** - men processed A1 as a scent, not as sexually stimulating **A1 is non-sexual to men** - gays processed EST as a scent, in a similar way as women (but it’s not exactly the same) **EST is non-sexual to gays & women** - men processed EST as activation of sexual areas of the brain **EST is sexual to men** ---
**Author:** ![delocc](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/delocc/32/1200_2.png) [@delocc](https://pheromonetalk.com/u/delocc)\ **Post date:** [October 11, 2011, 12:19am UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/11 "2011-10-11T00:19:32Z")
**I am a homosexual male, and will likely be testing A1 from LoveScent on myself and other gay men in the next few months. Will have to do a comparison report on the new AD mix meant to copy it. If anyone else has any field data about A1 on gay men, I’d really like to hear it.** ---
**Author:** ![delocc](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/delocc/32/1200_2.png) [@delocc](https://pheromonetalk.com/u/delocc)\ **Post date:** [October 11, 2011, 1:28pm UTC](https://pheromonetalk.com/t/a1-est-in-straight-men-gay-men-and-women/80/12 "2011-10-11T13:28:07Z")
I am a homosexual male, and will likely be testing A1 from LoveScent on myself and other gay men in the next few months. Will have to do a comparison report on the new AD mix meant to copy it. If anyone else has any field data about A1 on gay men, I’d really like to hear it.