# BI605906: a novel inhibitor of TNFα-dependent IκB degradation

**URL:** <https://pheromonetalk.com/t/bi605906-a-novel-inhibitor-of-tnf-dependent-i-b-degradation/66744>\
**Category:** Lounge\
**Created:** [December 17, 2016, 3:42am UTC](https://pheromonetalk.com/t/bi605906-a-novel-inhibitor-of-tnf-dependent-i-b-degradation/66744 "2016-12-17T03:42:02Z")\
**Posts on this page:** 4\
**Page:** 1

<div class="post-metadata">

**Author:** ![AdaBrown](https://avatars.discourse-cdn.com/v4/letter/a/4da419/32.png) [@AdaBrown](https://pheromonetalk.com/u/AdaBrown)\
**Post date:** [December 17, 2016, 3:42am UTC](https://pheromonetalk.com/t/bi605906-a-novel-inhibitor-of-tnf-dependent-i-b-degradation/66744/1 "2016-12-17T03:42:02Z")

</div>

BI605906, also called SCHEMBL4470165, is a novel pharmacological inhibitor of TNFα-dependent IκB degradation. In additonally, it also inhits expression of pro-inflammatory mediators IL-6, IL-1b, and CXCL1/2. IKKβ: IC50= 380 nM (when assayed at 0.1 mM ATP) In vitro: BI605906 not only prevents the phosphorylation of physiological substrates, such as p105 and RelA, but also the phosphorylation of the serine residues in IKKβ (Ser177 and Ser181) that trigger its activation.

---

<div class="post-metadata">

**Author:** ![Conjurator](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/conjurator/32/410_2.png) [@Conjurator](https://pheromonetalk.com/u/Conjurator)\
**Post date:** [December 26, 2016, 3:45am UTC](https://pheromonetalk.com/t/bi605906-a-novel-inhibitor-of-tnf-dependent-i-b-degradation/66744/2 "2016-12-26T03:45:35Z")

</div>

Wow, nice. I wonder what the next breakthrough will be.

---

<div class="post-metadata">

**Author:** ![Jdub](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/jdub/32/1399_2.png) [@Jdub](https://pheromonetalk.com/u/Jdub)\
**Post date:** [December 27, 2016, 3:58am UTC](https://pheromonetalk.com/t/bi605906-a-novel-inhibitor-of-tnf-dependent-i-b-degradation/66744/3 "2016-12-27T03:58:57Z")

</div>

I have no idea what this means…

---

<div class="post-metadata">

**Author:** ![Conjurator](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/conjurator/32/410_2.png) [@Conjurator](https://pheromonetalk.com/u/Conjurator)\
**Post date:** [December 27, 2016, 5:18am UTC](https://pheromonetalk.com/t/bi605906-a-novel-inhibitor-of-tnf-dependent-i-b-degradation/66744/4 "2016-12-27T05:18:18Z")

</div>

Neither do I, but it sounds exciting (lol) ^^.