# Estrenes for inducing hypothalamic effects **URL:** \ **Category:** Studies & Abstracts\ **Created:** [July 13, 2006, 11:11am UTC](https://pheromonetalk.com/t/estrenes-for-inducing-hypothalamic-effects/496 "2006-07-13T11:11:48Z")\ **Posts on this page:** 1\ **Page:** 1
**Author:** ![itwow](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/itwow/32/1493_2.png) [@itwow](https://pheromonetalk.com/u/itwow)\ **Post date:** [July 13, 2006, 11:11am UTC](https://pheromonetalk.com/t/estrenes-for-inducing-hypothalamic-effects/496/1 "2006-07-13T11:11:48Z")
> **[Estrenes for inducing hypothalamic effects - Pherin Corporation](https://www.freepatentsonline.com/5633392.html?s_id=25a1612519fd658844968b63e6f1d01c)** > > The invention relates to estrene steroids, which bind to neuroepithelial receptors. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more pharmaceut A = 1, 3, 5(10),16-Estratetraen-3-yl acetate B = Androsta-4,16-dien-3-one (i.e. **A1** ) C = 1,3,5(10),16-Estratetraen-3-ol (i.e. **EST** ) D = 3-Methoxy-Estra-1,3,5(10),16-tetraene E = Androsta-4,16-dien-3.alpha.-ol F = Androsta-4,16-dien-3.beta.-ol G = Androst-4-en-3-one H = Androsta-4,16-diene-3,6-dione J = 10,17-Dimethylgona-4,13(17)-dien-3-one K = 1,3,5(10),16-Estratetraen-3-ol-methyl ether [E0723-080 Steraloids] L = 1,3,5(10),16-Estratetraen-3-yl-propionate M = 1,3,5(10)-Estratrien-3-ol [R187798 (Aldrich)] E12/N1 = Estra-1,3,5(10),16-tetraen-3,6.beta.-diol E8/N1 = 3-MethoxyEstra-2,5(10),16-triene E7/N1 = 10-HydroxyEstra-4,16-dien-3-one OE = olfactory epithelium CNS = central nervous system EVG = Electro-vomeronasogram EOG = Electro-olfactgram **EFFECTS ON THE EVG** - A, C and D produced significant effects, that were consistent in all individual cases (males). - Vomeropherins active in male subjects produced larger responses than the diluent. B, F and similar concentrations of olfactants induced significantly reduced responses in the male VNO. - Among the vomeropherins, F produced the most significant differences within the group (females). Here, A induced a small effect that was significantly different from F. - In both populations of subjects, active vomeropherins induced receptor responses having large standard deviations. When the frequency distribution of the effects of A and F was studied in males and females respectively, we found a bimodal distribution. The significance of this observation is being studied at this point. E, a stereoisomer of F, does not stimulate the VNO in female subjects while F does. This is a demonstration of the specificity of VNO recognition of vomeropherins. In this regard it is interesting to note that while F is a superior vomeropherin, E generates a stronger olfactory effect than does F. **EFFECTS ON THE EOG** - In contrast to the sensitivity of the VNO to vomeropherins, the OE is less sensitive to these substances. This is true for both males and females. - In this study, B was the only vomeropherin having significant effect in the OE. - This finding reveals that at the concentrations used in our study, most vomeropherins are not effective stimulants of the olfactory receptors, but do have a clear effect on vomeronasal receptors. **REFLEX EFFECTS** - A and C induced a significant increase in skin temperature in 30 male subjects; however D induced significant temperature decrease. - In 30 female subjects, B and F evoked a significant increase in skin temperature compared to A and C. - In males, A, C and D significantly increased alpha cortical activity (D and A evoked the strongest effect). - In females, B or F applied to the VNO increased alpha cortical independent of the response of olfactory receptors. - The steroid E12/N1 exhibited the best EEG-alpha activity in men. The steroid E8/N1 exhibited the best EEG-beta activity in men. - The steroid E7/N1 exhibited the best EEG-alpha activity in women. Additionally, it is noted that E7/N1 exhibited excellent organ response, as shown by the EVG data, in both men and women, but there were gender differences in the CNS (high EEG-alpha in women, high EEG-beta in men). Sexual differences were noted in the specificities and effects of two groups of vomeropherins, A, C and D; and B and F.