# Releaser and Primer pheromones **URL:** \ **Category:** Men's Pheromone Advice & Field Reports\ **Created:** [January 7, 2008, 3:52pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110 "2008-01-07T15:52:25Z")\ **Posts on this page:** 15\ **Page:** 1
**Author:** ![nbully79](https://avatars.discourse-cdn.com/v4/letter/n/c68b51/32.png) [@nbully79](https://pheromonetalk.com/u/nbully79)\ **Post date:** [January 7, 2008, 3:52pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/1 "2008-01-07T15:52:25Z")
I think most of us know by now that the range of [pheromones](https://pheromonelabs.com/) can be divided into two categories: Releaser and Primer pheromones The details are available with a basic search but here is the gist. Releaser pheromones tend to trigger immediate responses in the recepient while Primer pheromones “primes” the recipient’s endocrine system to make future changes. I am guessing most of the pheromones that we use lie in the former category of releaser pheromones and we assume it will cause, if not immediate, then only slightly delayed reactions, although the reactions may not be expressed outwardly. Primer pheromones are held responsibly for the synchronising of menstrual cycles in women who live together (the McClintock effect). It is believed that two primer pheromones are responsible for this. Now in the whole wide range of experimones and putatives I am sure there are some pheromones which are primer pheromones. This leads me to think that we might be pooh-pooing some pheromones as ineffective because we don’t see typical releaser like effects that we are accustomed to seeing with pheromones. I also think that the primer pheromones might actually be more helpful in leaving a lasting impression. MHarris had earlier made a post about the possibility of primer pheromones in Cutler’s Athena product, the reason why it takes longer for some of it’s effects to build-up (mostly due to priming the user’s endocrine system). Have any of the users’ noticed “primer” effect with any of the putatives/MXs/experimones, where the target showed a much delayed resonse, probably after two or three meetings after she was consistently exposed to the same pheromone combinations in every meeting?🙂 ---
**Author:** ![Bella](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/bella/32/1738_2.png) [@Bella](https://pheromonetalk.com/u/Bella)\ **Post date:** [January 8, 2008, 5:35am UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/2 "2008-01-08T05:35:59Z")
I agree, it makes sense, it may very well be the ‘primer’ effect at work when people say they don’t notice effects or hits staight away. That certainly would explain alot. It all starts with the endocrine system doesn’t it? If we can identify which putatives/MXs/experimones give a ‘delayed’ effect, it certainly would help in understanding further how to work with them. Knowing this, maybe people wouldn’t be so quick to stop testing, and abandon these products too soon, labeling them as ineffective. nbully, i think Tater posted about this very thing when using Athena…but he said it took a month or two for the effects to become noticeable. ---
**Author:** ![tisha23](https://avatars.discourse-cdn.com/v4/letter/t/53a042/32.png) [@tisha23](https://pheromonetalk.com/u/tisha23)\ **Post date:** [January 8, 2008, 10:24am UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/3 "2008-01-08T10:24:43Z")
Great post Nbully 🙂 reps I am aware of it but its good to see it in a more technical explaination. Its why I always encourge people to test the products for at least a week. I feel even with the “releasers” there are some individuals who get a delayed response. We have mentioned this to those people having trouble when they first started out. With some of the primers you probably need even more time then a week. If you dont mind in the future I will refer them to this post to get a better understanding as to why they should test for a full week. I think experienced users will not Poo poo [advanced pheromones](https://pheromonelabs.com/product-category/advanced-pheromones/) so quickly because they relalize that it takes some time to get a feel for the product and responses you get with it. I tend to not post my findings till I have used at least half the bottle. This is just another reason why we encourage new users to stick with the consumer products at first. Ahh shoot I have to spread the love but I will be back to rep ya Nbully 😉 Tisha ---
**Author:** ![mark-in-dallas](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/mark-in-dallas/32/860_2.png) [@mark-in-dallas](https://pheromonetalk.com/u/mark-in-dallas)\ **Post date:** [January 8, 2008, 4:30pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/4 "2008-01-08T16:30:23Z")
Great write nbully, and you get my reps too. You have brought up an excellent point, and it got me to thinking about the much debated issue on whether the VNO is active in humans, or gone the way of the Appendix. I have read where the only pheromone proven to effect the VNO is Androstadienone. And although Androstadeinone is clearly a Releaser pheromone, I am wondering if the VNO might be responsible for receiving Primer signals and the olfactory membranes responsible for processing the Releaser pheros. An argument against this of course would be that if the VNO is actually active in humans and does connect to the preoptic area of the hypothalamus through the limbic system (hey I can read), and this being an old part of the brain reaponsible for regulating survival instincts, it would seem that Releaser pheromones would be processed through the VNO and Primer pheros through the olfactory membranes. But, you have got me to wondering! 😕 ---
**Author:** ![nbully79](https://avatars.discourse-cdn.com/v4/letter/n/c68b51/32.png) [@nbully79](https://pheromonetalk.com/u/nbully79)\ **Post date:** [January 10, 2008, 4:56pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/5 "2008-01-10T16:56:09Z")
Was out for a few days and didn’t see these posts until now. Thanks for the reps guys! 🙂 Mark, your theory may be true. I think we can move in the direction of confirming it once we identify some pheromones which are clearly ‘primer’. What muddies the field a bit, is that it might be possible for some pheromones to act as both releaser as well as primer. Bottomline is I will be keeping my mind open when testing putatives and new MXs! ---
**Author:** ![mark-in-dallas](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/mark-in-dallas/32/860_2.png) [@mark-in-dallas](https://pheromonetalk.com/u/mark-in-dallas)\ **Post date:** [January 10, 2008, 5:36pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/6 "2008-01-10T17:36:48Z")
And what muddies it even further, is even being able to determine long term effects are actually due to use of primer pheros. ---
**Author:** ![bosshank](https://avatars.discourse-cdn.com/v4/letter/b/91b2a8/32.png) [@bosshank](https://pheromonetalk.com/u/bosshank)\ **Post date:** [January 10, 2008, 6:48pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/7 "2008-01-10T18:48:08Z")
My comment would be: There is always the possibility that the primer pheromones are affecting the endocrine system in ways we will never be able to see or notice especially if it is in someone else. ---
**Author:** ![Socrates](https://avatars.discourse-cdn.com/v4/letter/s/3bc359/32.png) [@Socrates](https://pheromonetalk.com/u/Socrates)\ **Post date:** [January 10, 2008, 8:42pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/8 "2008-01-10T20:42:20Z")
I wonder where the following two types of ‘potential pheromones’ fits into this Releaser/Primer pheromone distinction? > [@Human Lipocalin Protein patents](https://pheromonetalk.com/t/human-lipocalin-protein-patents/4353): > > [Human phermone polypeptide - Patent 20030049726](http://www.freepatentsonline.com/20030049726.html) "Title: Human phermone polypeptide Document Type and Number: United States Patent 20030049726 Kind Code: A1 Link to this page: [Human phermone polypeptide - Patent 20030049726](http://www.freepatentsonline.com/20030049726.html) Abstract: Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides a new human pheromone polypeptide, designated “ZHMUP-2… “…The present invention provides a novel human phermone protein, designated “ZHMUP-2,” which is a member of the lipocalin family, and structurally related to murine major urinary proteins and porcine sex-specific salivary lipocalin. The present invention also provides ZHMUP-2 variant polypeptides and ZHMUP-2 fusion proteins, as well as nucleic acid molecules encoding such polypeptides and proteins, and methods for using these nucleic acid molecules and amino acid sequences…” “…The present invention describes novel uses for two human lipocalin proteins, glycodelin and Zlipo1, that are expressed in the genital tract and in the breast. Their expression in these tissues and their structural similarity to known rodent pheromones and pheromone carrier proteins indicate that these lipocalin proteins are useful in olfaction-mediated chemical communication between individuals…” > [@Patent for MHC ligand peptides for the modification of bodily odours](https://pheromonetalk.com/t/patent-for-mhc-ligand-peptides-for-the-modification-of-bodily-odours/3674): > > [http://www.freepatentsonline.com/20060039883.html](http://www.freepatentsonline.com/20060039883.html) Title: Biologically active compounds for the modification of bodily odours Document Type and Number: United States Patent 20060039883 … Abstract: The invention relates to the use of MHC ligands, e.g. MHC-binding peptides, for the manufacture of an agent for modifying bodily odours. Particularly, the invention is applicable in the field of cosmetics and medicine. Inventors: Boehm, Thomas (Vorstetten, DE), Milinski, Manfred (Plon, DE, US) … [http://www.freepatentsonline.com/20060039883.html](http://www.freepatentsonline.com/20060039883.html) "Title: **Biologically active compounds for the modification of bodily odours** Document Type and Number: United States Patent 20060039883 … Abstract: The invention relates to the use of MHC ligands, e.g. MHC-binding peptides, for the manufacture of an agent for modifying bodily odours. Particularly, the invention is applicable in the field of cosmetics and medicine. Inventors: Boehm, Thomas (Vorstetten, DE), Milinski, Manfred (Plon, DE, US) Application Number: 512555 Filing Date: 04/25/2003 Publication Date: 02/23/2006 … [0010] A preferred embodiment of the invention relates to the fields of cosmetics, particularly the manufacture of a perfume. Up to now the composing of perfumes was performed with natural or synthetic basic materials, based on empirical knowledge. In the light of the findings underlying the present invention the bodily odour can be influenced in a predetermined manner by means of adding defined MHC ligands or rather combinations of several MHC ligands to perfumes. Moreover, synthetic peptides can completely or at least partially substitute the costly substances present in perfumes so far, in order to achieve a cheaper and chemically defined composition of perfumes. … EXAMPLE 3 [0037] Olfactorial Quality of Peptides in Humans [0038] In order to test whether MHC class I peptides can be recognized by human beings, the following three experiments were conducted. Experiment 1: [0039] Several individuals were asked to evaluate the odour of a number of aqueous solutions. A prototypical MHC class I peptide (SLLPAIVEL), a known ligand of the A’02xx allele, or an equimolar mixture of the corresponding amino acids (S, L, P, A, I, V, E) were added to solvent (phosphate buffered saline) at final concentrations of 0.5 mM. These solutions were offered in pairs and the test persons were asked to decide whether the two solutions smelled similar or different. The results are shown in Table 4. The probands easily distinguish peptides from amino acids. Probands, however, could not distinguish ( 1/13) an amino acid containing solution from the pure solvent, suggesting that peptides carry a distinct olfactorial quality. Experiment 2: [0040] Two female individuals whose HLA-haplotypes were known were asked to evaluate the quality of two different solutions. Solution A consisted of a perfume base (Moschus: 1 g in 70 g 96% aqueous ethanol plus 10 g distilled water) only, solution B contained in addition the SLLPAIVELL peptide (final concentration 100 nM). The probands were asked which solution they would prefer as their own perfume. The results are shown in Table 5. Proband 1, who carries the A’02’’ allele, prefers the spiked solution, proband 2, who does not carry an A’02 allele, rejects it. In other words, although proband 1 has little preference for the perfume base, the addition of a MHC class I self-peptide increases the attractiveness. Proband 2, in contrast, shows a higher initial preference for the perfume base; however, in this case, the attractiveness is drastically diminished by the addition of a non-self-MHC class I peptide. This suggests that the presence of peptides is differentially assessed depending on the proband’s HLA status. Experiment 3: [0041] Proband 1 was asked to compare SLLPAIVELL peptide (solution C) against a solution containing a mutated version (SALPAIVELA, solution D). In the latter peptide, the anchor residues (Ref. 2) that mediate binding (Ref. 33) to the MHC molecule were changed to alanine; in essence, this peptide would not be able to bind to an A’02 molecule and hence would not function as a self-peptide. In this particular instance, the perfume base was Ambra (1 g in 70 g 96% aqueous ethanol plus 10 g distilled water). The proband was asked which solution she would prefer as her own perfume. The results indicate a preference for solution C over D (scores 4.6 vs 2.9; score width 0 to 7). This indicates that the amino acid composition of peptides modifies their olfactorial quality. [0042] All three experiments show that humans are capable of detecting peptides in aqueous solutions and that their olfactorial quality may be differentially perceived according to the HLA status of the proband. Thus, peptides may modify the quality of perfume compositions and hence body odour…" [http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.ecolsys.37.091305.110242](http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.ecolsys.37.091305.110242) ([http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.ecolsys.37.091305.110242](http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.ecolsys.37.091305.110242)) **Abstract** **Annual Review of Ecology, Evolution, and Systematics** Vol. 37: 159-186 (Volume publication date December 2006) (doi:10.1146/annurev.ecolsys.37.091305.110242) First published online as a Review in Advance on July 27, 2006 **The Major Histocompatibility Complex, Sexual Selection, and Mate Choice** **Manfred Milinski\*\*\*\*­** Department of Evolutionary Ecology, Max Planck Institute of Limnology, D-24306 Pherlureön, Germany; email: [milinski@mpil-ploen.mpg.de](mailto:milinski@mpil-ploen.mpg.de) To maintain sexual reproduction, recombination of good genes through selective mate choice must achieve a twofold genetic benefit in each generation. “Fragrant” immune genes of the major histocompatibility complex (MHC) allow the choosy sex to complement her own set of alleles with a more or less diverse set of male alleles to reach an optimal number of different MHC alleles for the offspring. The optimal complement from the partner should include those MHC alleles that provide resistance against the current parasites, which could be revealed by the expression of costly secondary sexual characters. This maximizes resistance to ever-changing infectious diseases. Because the advantage of sex must be produced through recombination, assortative mating should combine currently advantageous MHC alleles. Preferring just MHC dissimilar mates is only a best-of-bad-job rule. MHC ligand peptides may be the natural “perfume” that reveals a potential partner’s MHC genetics probably in all vertebrates. Perfumes may mimick MHC related signals. ---
**Author:** ![Socrates](https://avatars.discourse-cdn.com/v4/letter/s/3bc359/32.png) [@Socrates](https://pheromonetalk.com/u/Socrates)\ **Post date:** [January 11, 2008, 8:39am UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/9 "2008-01-11T08:39:48Z")
**From the study pasted in below it says:** “In a broader perspective, pheromones can be classified as primers, signalers, modulators, and releasers. There is good evidence to support the presence of the former three in humans. Examples include affects on the menstrual cycle (primer effects); olfactory recognition of newborn by its mother (signaler); individuals may exude different odors based on mood (suggestive of modulator effects). **However, there is no good evidence for releaser effects in adult humans.** ” **I wonder can the current crop of human pheromones/putatives be divided up into primers, signalers and modulaters?** **1: [Anat Rec A Discov Mol Cell Evol Biol.](javascript:AL\_get(this, ‘jour’, ‘Anat Rec A Discov Mol Cell Evol Biol.’)😉 2004 Nov;281(1):1201-11.** **Facts, fallacies, fears, and frustrations with human pheromones.** **Wysocki CJ** ([http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Wysocki%20CJ"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed\_ResultsPanel.Pubmed\_RVAbstractPlus](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Wysocki%20CJ%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus)), **Preti G** ([http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term="Preti%20G"[Author]&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed\_ResultsPanel.Pubmed\_RVAbstractPlus](http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Preti%20G%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus)). Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA. [wysocki@monell.org](mailto:wysocki@monell.org) Among primates in general, pheromones are of variable importance to social communication. Data on humans have generated the greatest controversy regarding the existence of pheromonal communication. In this review, the likelihood of pheromonal communication in humans is assessed with a discussion of chemical compounds produced by the axilla that may function as pheromones; the likelihood that the vomeronasal organ (VNO), a putative pheromone receptor organ in many other mammals, is functional in humans; and the possible ways pheromones operate in humans. In the human axilla, the interactions between the cutaneous microflora and axillary secretions render this region analogous to scent glands found in other primates. Both the chemistry of axillary secretions and their effects on conspecifics in humans appear to be analogous to other mammalian pheromone systems. Whichever chemical compounds serve a pheromonal function in humans, another unknown is the receptor. Although the VNO has been implicated in the reception of pheromones in many vertebrates, it is not the only pathway through which such information has access to the central nervous system; there is ample evidence to support the view that the olfactory epithelium can respond to pheromones. Furthermore, if a chemical activates receptors within the VNO, this does not necessarily mean that the compound is a pheromone. An important caveat for humans is that critical components typically found within the functioning VNO of other, nonprimate, mammals are lacking, suggesting that the human VNO does not function in the way that has been described for other mammals. In a broader perspective, pheromones can be classified as primers, signalers, modulators, and releasers. There is good evidence to support the presence of the former three in humans. Examples include affects on the menstrual cycle (primer effects); olfactory recognition of newborn by its mother (signaler); individuals may exude different odors based on mood (suggestive of modulator effects). However, there is no good evidence for releaser effects in adult humans. It is emphasized that no bioassay-guided study has led to the isolation of true human pheromones, a step that will elucidate specific functions to human chemical signals. (c) 2004 Wiley-Liss, Inc. PMID: 15470677 [PubMed - indexed for MEDLINE] **And from the article below a classic example is given of a releaser pheromone, Androstenone in female pigs (sows), and “There is no good evidence that the kind of pheromones people are selling releases a specific behavioral sequence in humans” …** [C&EN: SCIENCE & TECHNOLOGY - EXPLORING THE CHEMICAL SENSES](http://pubs.acs.org/cen/topstory/8001/8001sci1.html) “The products take advantage of the public’s ignorance of what pheromones do, Wysocki explains. **Androstenone, for example–the pheromone of male pigs and the “active ingredient” in many [pheromone perfumes](https://a314.com/shop/)–is called a releaser pheromone because it releases a sequence of gross behavioral changes when it is detected by a sow in heat: The sow arches its back, assumes the mating stance, and is ready to mate. “There is no good evidence that the kind of pheromones people are selling releases a specific behavioral sequence in humans,” he says.** However, a more subtle type of pheromone, called primer pheromones, affects female reproductive development, cyclicity in females, and female hormonal surges. For example, in 1998, researchers at the University of Chicago showed that secretions from female armpits cause women who live together to have synchronous menstrual periods. The work is regarded as the first real proof of chemical communication among women.” ---
**Author:** ![nbully79](https://avatars.discourse-cdn.com/v4/letter/n/c68b51/32.png) [@nbully79](https://pheromonetalk.com/u/nbully79)\ **Post date:** [January 11, 2008, 5:24pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/10 "2008-01-11T17:24:13Z")
Thanks for bringing this out Visionary! This looks like a much wider distinction of pheromones based on effects. For all common purposes might be easier to group the pheromones in the broader two categories; signalers and modulators might be grouped into releaser category as their effects seem to be immediate. Now about the absence of releaser effects, Androstenone might actually be the one with the most readily noticeable releaser effects of all other pheromones, even in humans (bringing out aggression, sexual readiness for ovulating women or in sexual situations). Androstenone also seems to show typical signaler (signals that wearer is physically strong, a big bad brute at high doses), and modulator (changes mood of people around them, at high doses ruins the mood of men and definitely of women during their period) effects. We consider all these effects to be typical releaser effects since they show up immediately and don’t require ‘priming’. > [@Socrates](#): > > **From the study pasted in below it says:** > > “In a broader perspective, pheromones can be classified as primers, signalers, modulators, and releasers. There is good evidence to support the presence of the former three in humans. Examples include affects on the menstrual cycle (primer effects); olfactory recognition of newborn by its mother (signaler); individuals may exude different odors based on mood (suggestive of modulator effects). **However, there is no good evidence for releaser effects in adult humans.** ” > > **I wonder can the current crop of human pheromones/putatives be divided up into primers, signalers and modulaters?** > [@Socrates](#): > > **And from the article below a classic example is given of a releaser pheromone, Androstenone in female pigs (sows), and “There is no good evidence that the kind of pheromones people are selling releases a specific behavioral sequence in humans” …** > > [C&EN: SCIENCE & TECHNOLOGY - EXPLORING THE CHEMICAL SENSES](http://pubs.acs.org/cen/topstory/8001/8001sci1.html) > "The products take advantage of the public’s ignorance of what pheromones do, Wysocki explains. **Androstenone, for example–the pheromone of male pigs and the “active ingredient” in many pheromone perfumes–is called a releaser pheromone because it releases a sequence of gross behavioral changes when it is detected by a sow in heat: The sow arches its back, assumes the mating stance, and is ready to mate. “There is no good evidence that the kind of pheromones people are selling releases a specific behavioral sequence in humans,” he says.** ---
**Author:** ![nbully79](https://avatars.discourse-cdn.com/v4/letter/n/c68b51/32.png) [@nbully79](https://pheromonetalk.com/u/nbully79)\ **Post date:** [January 11, 2008, 5:53pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/11 "2008-01-11T17:53:32Z")
Alpha Androstenol, Androstadienone, Est, TAA definitely seem to be modulator pheromones with their overt impact on mood of people. Also probably TAC and P93. I will venture a guess about others. Beta-Androstenol (and also Alpha Androstenol to some extent) seems to be a signaler more than modulator as the wearer gives a vibe (sends a signal) that he/she is a good listener. P74 also seems to fall into a signaler category (sends a cool guy vibe). Also TAF might fit in this category (screams “look at me I am new and unique”). TAH and TAL seem to be signalers as well (“cute woman” or “strong woman” respectively) In most cases the effects of _modulation_ and _signaling_ might lead to _releaser_ effects (i.e. immediate behavioral changes towards the wearer), which makes the distinction between these three types so much more harder. ---
**Author:** ![Socrates](https://avatars.discourse-cdn.com/v4/letter/s/3bc359/32.png) [@Socrates](https://pheromonetalk.com/u/Socrates)\ **Post date:** [January 11, 2008, 7:45pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/12 "2008-01-11T19:45:54Z")
Thanks for the feedback Nbully and starting this thread - its turning out quite fruitful! Pages 10-12 and 18-21 of this article have more detailed information on ‘the four types of pheromones’: [www.diva-portal.org/diva/getDocument?urn\_nbn\_se\_uu\_diva-5880-2\_\_fulltext.pdf](http://www.diva-portal.org/diva/getDocument?urn_nbn_se_uu_diva-5880-2__fulltext.pdf) In this article Androstadienone seems to be put forward as a putative human Modulator pheromone… **I am not sure whether the Priming pheromone(s) for human female menstrual synchronicity has been identified. Anyone know what it might be (the top of page 18 of the article mentions that (Alpha) “Androstenol has also been mentioned has also been suggested as a potential regulator of the menstrual synchrony phenomena”)?** There is an interesting discussion on the Signalling pheromones in humans on pages 20-21 of the article. The obvious human signalling pheromones would be the HLA molecules I would think. \*\*Now I would love to try some of these patented HLA molecules that were mentioned in my first post of this thread - the patent ‘inventors’ are Thomas \*\ ***Boehm and Manfred Milinski. I wonder if these could be put into the putatives or if any products are already available that use such molecules?** -Visionary ---
**Author:** ![MarkL](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/markl/32/825_2.png) [@MarkL](https://pheromonetalk.com/u/MarkL)\ **Post date:** [January 12, 2008, 11:27am UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/13 "2008-01-12T11:27:44Z")
> [@nbully79](#): > > Thanks for bringing this out Visionary! … > > Now about the absence of releaser effects, Androstenone might actually be the one with the most readily noticeable releaser effects of all other pheromones, even in humans … Maybe androstenone sends the message _ **“I’ve been working where there are mating pigs.”** _ 🙂😃🙄🆒 ---
**Author:** ![nbully79](https://avatars.discourse-cdn.com/v4/letter/n/c68b51/32.png) [@nbully79](https://pheromonetalk.com/u/nbully79)\ **Post date:** [January 12, 2008, 6:15pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/14 "2008-01-12T18:15:46Z")
> [@MarkL](#): > > Maybe androstenone sends the message _ **“I’ve been working where there are mating pigs.”** _ 🙂😃🙄🆒 😃 😃 Yup definitely a signaler in that case!😛 ---
**Author:** ![mark-in-dallas](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/mark-in-dallas/32/860_2.png) [@mark-in-dallas](https://pheromonetalk.com/u/mark-in-dallas)\ **Post date:** [January 12, 2008, 7:16pm UTC](https://pheromonetalk.com/t/releaser-and-primer-pheromones/8110/15 "2008-01-12T19:16:22Z")
> [@MarkL](#): > > Maybe androstenone sends the message _ **“I’ve been working where there are mating pigs.”** _ 🙂😃🙄🆒 Oh hell MarkL, now you got me thinking I gotta throw away all my products with Androstenone in them, before women start thinking I’ve been playing with pigs. 🙄