I can’t speak on the difference Depo might be making, maybe someone else can. But I had something similar happen not long ago, and here is what I did:
I stopped using pheros for a few days. I think I went four.
I started supplementing with L-Phenylalanine and L-Tyrosine. Some recommend against taking both at the same time as phenylalanine is converted into tyrosine, but unless you are taking massive doses, it should not negatively affect you. I took 500mg of each per day in the am. I also took Schizandra and Rhodiola in the am and with dinner. I don’t remember the dose I took of those, but I followed the manufacturer’s (Nature’s Way) recommendations. I also took 5-HTP in the evening not long before bed.
These supplements help recharge your neurotransmitters which can become overloaded from all the pheros you are throwing at them day after day. A few people have talked on the board in the past about “peptide preloading” (https://pheromonetalk.com/t/help-advice-a314-is/565/8)and I think a couple swear by Life Enhancement’s FastBlast (Life Enhancement:: Product > FastBLAST™), but I prefer to keep my caffeine intake to a minimum, and that product is also a lot more expensive per serving than just buying a bottle of L-Phenylalanine and/or L-Tyrosine and taking it as needed. YMMV.
You could also try just limiting the pheros you use to something uplifting for the time being, like Instant Female Magic, Instant Shine, or straight TAA.