# The Truth about Pheromones? **URL:** \ **Category:** Pheromone Theory & Molecules\ **Created:** [June 19, 2009, 11:56am UTC](https://pheromonetalk.com/t/the-truth-about-pheromones/30004 "2009-06-19T11:56:00Z")\ **Posts on this page:** 4\ **Page:** 1
**Author:** ![jvkohl](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/jvkohl/32/1297_2.png) [@jvkohl](https://pheromonetalk.com/u/jvkohl)\ **Post date:** [June 19, 2009, 11:56am UTC](https://pheromonetalk.com/t/the-truth-about-pheromones/30004/1 "2009-06-19T11:56:00Z")
I’m not sure how to find Part 1, but here’s the latest from Psychology Today [The Truth About Pheromones: Part 2 | Psychology Today](http://www.psychologytoday.com/blog/smell-life/200906/the-truth-about-pheromones-part-2) James V. Kohl `http://www.pheromones.com` ---
**Author:** ![Domnk](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/domnk/32/2269_2.png) [@Domnk](https://pheromonetalk.com/u/Domnk)\ **Post date:** [June 19, 2009, 8:10pm UTC](https://pheromonetalk.com/t/the-truth-about-pheromones/30004/2 "2009-06-19T20:10:14Z")
Here you go my friend, [The Truth About Pheromones: Part 1 | Psychology Today](http://www.psychologytoday.com/blog/smell-life/200905/the-truth-about-pheromones-part-1) 🙂 Dominick > [@jvkohl](#): > > I’m not sure how to find Part 1, but here’s the latest from Psychology Today > > [The Truth About Pheromones: Part 2 | Psychology Today](http://www.psychologytoday.com/blog/smell-life/200906/the-truth-about-pheromones-part-2) > > James V. Kohl > `http://www.pheromones.com` ---
**Author:** ![Olfact\_Amorous](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/olfact_amorous/32/434_2.png) [@Olfact\_Amorous](https://pheromonetalk.com/u/Olfact_Amorous)\ **Post date:** [December 6, 2009, 1:42pm UTC](https://pheromonetalk.com/t/the-truth-about-pheromones/30004/3 "2009-12-06T13:42:13Z")
Oooo that McClintock Effect seems interesting. I just couldnt imagine why girls that would congregate for extended periods of time would suddenly pick up the same intervals. ---
**Author:** ![jvkohl](https://sea2.discourse-cdn.com/flex016/user_avatar/pheromonetalk.com/jvkohl/32/1297_2.png) [@jvkohl](https://pheromonetalk.com/u/jvkohl)\ **Post date:** [December 6, 2009, 2:32pm UTC](https://pheromonetalk.com/t/the-truth-about-pheromones/30004/4 "2009-12-06T14:32:49Z")
> [@Olfact\_Amorous](#): > > Oooo that McClintock Effect seems interesting. I just couldnt imagine why girls that would congregate for extended periods of time would suddenly pick up the same intervals. The McClintock Effect is “ovulatory synchrony.” In women, in occurs over several months exposure to other women. The hormone changes appear to be the same across species, and the primary hormone involved is luteinizing hormone (LH). Rachel’s book is informative for the masses, but doesn’t provide the neuroscientific substance that is required to take interested parties to the next level. It’s great that she has helped to popularize the concept, but there’s much more to it that any general audience book can convey. For example, she wrote about (in the article) the absence of a human VNO. In recent years, the issue of how human [pheromones](https://pheromonelabs.com/) elicit effects when there is no functional human VNO has been better detailed. Here is the latest information that, as you will see, continues along the lines of my work, beginning about 20 years ago. The human VNO was a marketing ploy, which has substantially delayed research on human pheromones, their effect on hormones (like LH), and subsequent affects on behavior. Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones In Press, _Uncorrected Proof_\*, Available online 27 November 2009 \*Julie Bakker, Sylvie Pierman, David González-Martínez ## Abstract: Pheromones have been shown to induce sexually dimorphic responses in LH secretion. Here we asked whether the sexually dimorphic population of kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) could relay sexually dimorphic information from the olfactory systems to the GnRH system. Furthermore, we analyzed the effects of aromatase mutation (ArKO) and thus the role of estradiol on RP3V kisspeptin neuronal numbers and on the response of these kisspeptin neurons to same- versus opposite-sex urinary pheromones. Exposure to male but not female urinary odors induced Fos protein in kisspeptin neurons in the RP3V of female wildtype (WT) mice, suggesting that these kisspeptin neurons may be part of the neural circuitry that relays information from the olfactory brain to the GnRH system in a sexually dimorphic manner. Male pheromones induced Fos in kisspeptin neurons in ArKO females, albeit significantly less compared to WT females. The sexual differentiation of kisspeptin neuronal number was lost in ArKO mice, i.e. the number of kisspeptin-immunoreactive neurons in the RP3V of ArKO females was as low as in male mice, whereas male ArKO mice had somewhat increased numbers of kisspeptin neurons. These results suggest that the sex difference in kisspeptin neuronal number in WT mice reflects an organizational action of estradiol in females. By contrast, the ability of male urinary pheromones to activate kisspeptin neurons in WT females may not depend on the organizational action of estradiol since ArKO females still showed some Fos/kisspeptin co-activation. The title of my first presentation to a scientific congress was Luteinizing hormone: ( **LH** ) **the link between sex and the sense of smell**? The question mark in my title was added because – at that time – no one could be sure that LH was the link. Now, more people know that it is! Evidence of this knowledge is in the first line of the abstract (above): **“Pheromones have been shown to induce sexually dimorphic responses in LH secretion.”** my **emphasis** added. When published, this article will help to further establish the validity of the model I’ve presented since the early 1990’s. In this article, Julie Bakker’s group has helped to detail a sexually dimorphic pathway from pheromones to hormones (and thus to behavior) in mammals. We can be relatively sure humans have a similar sexually dimorphic pathway, because of our sexually dimorphic LH response to putative human pheromones. I met Julie at a conference in 1995. At the last two scientific conferences I attended, the presentations on kisspeptin assured me it would be part of the big picture. Even though the abstract may not make sense to most people, you can expect some journalistic liberties to be taken in order to help more people understand after the article is published. Meanwhile, as some of you already know, androstenol alters LH in women. That’s one reason why androstenol is in Scent of Eros products. James V. Kohl `http://www.pheromones.com` Human Pheromones: Scent of Eros