I was reading an interesting article in omni the other day about mones. It mentions that as men age their mone levels of -none and -nol goes down but the levels of -rone goes up 
Yup - This is a well known thing.
Which means that when you get to the likes of my age, you can have a lot of fun playing with a much wider range of none doses and moderating pheros in mixes that would get younger guys ghosted from the off. 
So does this also means that guys at my age of 40 can benefit from more from high -none and -nol i.e Ammo, TUTH, IO etc… but they will get minimum benefit from A314?
Certainly not that guys our age get minimum benefit from A314, but we can use more none than the young bucks. That opens for some nice combos. Of course the young men may have the same effects naturally with only A314 and their own none production. Us old geezers get like a second chance with additional mones.
As I understand, nol is hard for anyone to get a bad OD off. I don’t really know cause I don’t use it all that much.
A314 works just fine for me at 40.
I’ve still found plenty of benefit from A314 in my 40s but yes, maybe it does work in a different, more subtle way.
This also may be the reasoning behind the A314 Extra None Edition, to help balance things for older guys? And plenty of us from mid 30s-up have had good results from using standard A314 with the likes of TUTH/NPA/None itself but the balancing pheros in Ammo may detract from A314 somewhat.
Its not a bad OD but IME, too much nols can get a bit giddy, then lead to you feeling a bit drained after a while.
a314 on my 43yrold self really drives home the mature captain of industry vibe. Totally useful for business AND pleasure.