well, high does of Shine tend to give me and some other people headaches. i’ve noticed so such signs of that up to the 112.5 mcg level with p103.
Spaceland just makes near me sort of muddled and giggly for no reason. p103 has more of a “im smiling because i’ve been momentarily freed from my emotional baggage, and its so niiiiiice to be free” sort of feeling.
As for the acclimation you mention, i think that is uniform to all pheromones, but with p103(my bottle is now empty, so it doesn’t matter) i would just space out my uses enough to keep the self effects. I like them that much. I found it much more useful on myself than i did on others anyways.