So I am wondering....

How did AD or the maker of the mones here realize how to make formulations to elicit certain feelings or responses? For instance, AD said we want to formulate a mixture that will make people more trusting (a la IH). Same for making people chatty (IO), making the wearer feel like a jerk (IJ). I am just wondering how was that accomplished? How did they know which molecules to incorporate into the formulation?

Through testing. Hence why we have MX’s and Putatives