So I have been reading, and reading, and reading posts. There is one question that comes into mind when I think about synthetic pheromones. Your body believes that the pheromones that you created come from you right? Over time does the body begin to decrease natural pheormone production in response to the synthetic pheromones? I know that if you continue to use certain hormones, the body may reduce or even stop the production of those same hormones in an attempt to maintain balance. This is why hormones have to cycled. Does anyone know if this would hold true with pheromones?
JosieWilder,
Here is your anwswer:
Enjoy… I know I did… I love the knowledge on this Forum!!!
-Reese
Thanks bro. I’m glad I finally got an answer to that. There is quite a bit of information on here. Everything from neuroscience, to parfum dvelopment, and body language. Then throw in the knowledge of hypnosis and NLP and you can real understand how we work.
That link isn’t working anymore, does anyone have the answer?
Yes, it would be an interesting read. Though I’m pretty sure that the answer is no, the mone use will not create physiological changes in the user since we don’t introduce them into our bodies but only wear them on our skin.
Fixed link.
I would agree with Xiphoid’s general remarks. An example of downregulation would be chronic use of Valium. GABA becomes downregulated. Sudden withdraw of the drug would increase seizure risk. Investigational threapies for mood disorders caused by downregulation of endogenous GABA involve progestagen neurosteroids. They could be used or tested as sprays. While downregulation via phero sprays is not proved, the concept is prima facie viable.
Post-2010, the VNO is mostly seen as vestigial in adult humans (vs. lower vertebrates). Prolactin is also vestigial in human males, who don’t breastfeed. Olfactory neurons transduct odor molecules into nerve impulses thence to the olfactory bulb or main olfactory system. The VNO was said part of the accessory olfactory system. The anterior, distal skull boney material is porous. Neurons pass through it and to the bulb. The main olfactory system passes sensory input further to the brain. However, communication is bidirectional. Mood and activity higher in the brain pass signals back to the bulb. Our present emotions interpret our smells and vice versa simultaneously. Some volatile molecules could even pass through porous bone into the cranium and the bulb directly. Transdermal and trans-blood-brain delivery of the molecule would not be strictly required. Transduction means that the molecule itself affects the brain via electrochemical signaling. It is not necessary that the the chemical flow into the brain itself, as would be so with an injected drug.
This post shows the complexity of feedback, and why understanding it in the phero context defies easy understanding. As it states, negative and positive feedback aims at normal thyroid output. However, this can be perturbed. Absent organic disease, it should be temporary. Feedback acts like a mechanical governor: as faster the speed, as more the governor slows the speed to the specified RPM, to prevent overload. Downregulation/upregulation makes the most sense it terms of pheros. There is also the serotonin transporter mechanism. As explained, it recycles serotonin. And, yes, perturbations could affect sensitive persons with long-term use. For similar reasons, I fully expect genetic polymorphisms do affect phero effects. Either a substance is psychoactive or not. If active, it’s governed by the same neurophysiology or neurotransmitter uptake as any other neuroactive compound, including alcohol, OTC meds, herbals, aromatherapy. A chemical is a chemical is a chemical. However, not being in the bloodstream (at the olfactory receptors, not in the blood), mones don’t follow the same pharmacokinetics of half life, serum/plasma concentration, etc. They aren’t in serum or plasma. They aren’t taken internally.
http://en.wikipedia.org/wiki/Hypothalamic%E2%80%93pituitary%E2%80%93thyroid_axis#Physiology
Final point. If I inject you with a large pentobarbital bolus, the body cannot metabolize it quickly. You will experience coma and death. If I spray you with 900 sprays of TAK, there is nothing to metabolize. The effects are limited by the ability of the molecule to bind olfactory receptors. You cannot be poisoned by the odor of cookies. Even being at a mortuary with a two-weeks decomposed corpse, it will sicken you but not kill you. And then, the sickness is mostly a natural reaction.