You can, you’ll have to do it regularly, but it won’t remove the effects entirely. You’ll get a core or diluted effect, but truly exceptional “special effects” will be removed or muted in most cases. Sort of like getting the milk, but not the cream on top.
Personally, I stay away from high amoubts of A1 and -none, and while I’ve been exposed to ample amounts of each, I’ll still have stronger responses when I use larger amounts them for the first time in a long time.
However, I don’t ever get the over the top effects I did when I used them for the very first time. I think the very excessive, first time effects involved my own body trying to find homeostasis.