The health effects that you are most likely to experience are the result of burnout. Long term continuous exposure to artificially high levels of pheromones can create synaptic fatique that manifests itself in variety ways. Emotional indifference, depression, panic attacks, along with all the physical symptoms that come with these mental states.
Like you, I’m a heavy user of A314. I apply 2-3 drops 1-2 hours before I get into the city. About 12 hours later I apply 3 drops an hour before I return to the office. And I don’t hesitate to take a quick draw squeeze in any threatening situation.
The was a time when I wore considerably more. A line across my palm about an inch long was a regular dose. My purpose at that point was for the world to get the hell out of my way. And stay out. It worked.
That was the old musky A314. I could not even get close to that with the new clean/laundry smell A314 without getting queasy. Those were the days.
At these application levels cleaning becomes important in order to control exposure so that yourself and the people around you are not exposed to residual buildup on your clothing or linens. It is important to use oxygenated product like Oxyclean in your laundering.
I try to go without pheros or with a different phero signature on every 3rd to 4th meeting with each group of people that I deal with. Their respect / deference responses continue as usual. It seems to become an ingrained behavior.
There is considerable evidence that varying signature reinforces and strengthens response to the original primary signature.