Androstenone (None) is probably the main one that is likely to rub people-up the wrong way. Which is annoying as it is also the phero most widely useful for sexual/attraction purposes.
Usual reason is that they are wearing too much None and often around younger people who can do better with less rather than more by way of dose. Some time spent testing to establish your effective dose range across a variety of situations/environments will help you here.
Also pay attention to balancing/moderating mones that help diffuse the potential for negatives - but don’t obliterate the None with socials, look to complement/round it out instead.
Ammo is pretty well balanced but it can still cause some people problems - sometimes extra moderation helps but often its as simple as using less. What age are you and how many sprays were you using? Also, was this the standard or 'Heavy@ version - it will say on the bottle.
Nols - yes they can cause headaches and a tired/drawn/fidgety feeling, IME most often when worn at high dose or with prolonged use/topups. Keeping yourself well-fed and hydrated helps a lot IME, as does the occasional pause to rest a while. Adjustnent is also a factor and you may find you get-on much better after a few outings.
IS - not really, in fact it has its own ‘crash’ issues where if you wear too much too long you will know about it! So short term mood-lift aside, its not the answer. It also has less by way of moderation effects compared to Nols or putatives like P96 or P130 (excellent around younger women) so it is more a steering product. Saying that, Ammo/IS is an excellent social/attractive combo for a lot of people over a wide age range.
Fortunately, IS is about the fastest phero to adjust to, so for most people, any problems go away after a few outings.
Lastly, some scents can cause you problems. I had to give-up on the standard Ammo (FF21) scent for this reason - headaches/mild irritation but the World Edition (FF22) and Blue Summer (FF23) scents were fine. So taking it in a different scent could be an answer.
Moving your app points to the periphery will help but most of the further flung areas don’t diffuse so well so dose adjustment may be needed, also sexuals always seem to do best for me on the neck/throat area - Best diffusion and think how an interaction builds - you want the maximum impact when they are physically closest to you. 