Dihydrotestosterone (DHT) as a pheromone

Pheromone Science Pheromone Theory & Molecules
1

Dihydrotestosterone (DHT) is available in cream form (called Andractim/Stanolone) for the treatment of Gynecomastia (breast enlargment in males) in some countries. DHT is known as a potent metabolite of Testosterone which has been implicated as a cause of Male Pattern Balding.

Anyway maybe if someone has the chance to obtain this molecule legally, they could get ahold of DHT and try it as a pheromone? Just try to avoid putting too much on the skin obviously and be careful if you do try it. If DHT is prescription-only in the USA or unavailable, then Androtics could not sell it.

1: Physiol Behav. 1979 Jul;23(1):207-9. Links

The sexual attractiveness of male rats: olfactory and behavioral components.

· Drewett RF ("Drewett RF"[Author] - Search Results - PubMed),
· Spiteri NJ ("Spiteri NJ"[Author] - Search Results - PubMed).
Female rats are more attracted to intact than to castrated males. In this study, we compared the approach of female rats, in a straight runway, to (1) castrated males, which neither smell nor behave like intact males, (2) castrated males treated with dihydrotestosterone (DHT), which smell like intact males but behave like castrate males, and (3) castrated males treated with DHT and estradiol benzoate (EB), which both smell and behave like intact males. It was found that females ran faster to DHT males than to the castrate controls; and faster to the DHT-EB group than to the DHT group. Thus the odour and the sexual activity of male rats are independent effective sources of incentive to females.
PMID: 515212 [PubMed - indexed for MEDLINE]

1: Horm Behav. 1985 Sep;19(3):231-6. Links

Induction of ear wiggling in the estrous female rat by gonadectomized rats treated with androgens and estrogens.

· Vreeburg JT ("Vreeburg JT"[Author] - Search Results - PubMed),
· Ooms MP ("Ooms MP"[Author] - Search Results - PubMed).
Intact and gonadectomized male and female rats treated with estradiol and/or dihydrotestosterone were introduced into the cage of estrous female rats. For 3 min the number of periods with ear wiggling displayed by the estrous female and the total duration of the periods with ear wiggling were recorded. It was found that estrous females showed about twice as much ear wiggling in the presence of intact males as in the presence of gonadectomized male and female rats. However, gonadectomized male and female rats treated with dihydrotestosterone induced as much ear wiggling as intact males did. In contrast, administration of estradiol to the gonadectomized stimulus rats did not affect the rate of ear wiggling of the estrous females. Estrous females showed the lowest rate of ear wiggling in the presence of intact female rats. It has been suggested that dihydrotestosterone-treated male and female rats have an odor which sexually excites estrous female rats.
PMID: 4054849 [PubMed - indexed for MEDLINE]

1: J Vet Med Sci. 2001 Mar;63(3):347-8. Links

Induction of primer pheromone production by dihydrotestosterone in the male goat.

· Iwata E ("Iwata E"[Author] - Search Results - PubMed),
· Wakabayashi Y ("Wakabayashi Y"[Author] - Search Results - PubMed),
· Matsuse S ("Matsuse S"[Author] - Search Results - PubMed),
· Kikusui T ("Kikusui T"[Author] - Search Results - PubMed),
· Takeuchi Y ("Takeuchi Y"[Author] - Search Results - PubMed),
· Mori Y ("Mori Y"[Author] - Search Results - PubMed).
Laboratory of Veterinary Ethology, The University of Tokyo, Japan.
Castrated goats were treated with dihydrotestosterone (DHT) for four weeks. Skin samples were collected from the head and the rump regions before and after the DHT treatment. The primer pheromone activities of these samples were assessed neurophysiologically by recording electrophysiological manifestations of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator activity. Pheromone activity was detected in both the head and rump skin samples following the DHT treatment, although the development of sebaceous glands was limited to the head region. Taken together with our previous finding that testosterone treatment results in the appearance of primer pheromone activity in the skin sample of the head region but not of the rump region. these observations suggests that the regional difference of pheromone production would be ascribed to intrinsic expression levels of 5alpha-reductase, an enzyme converting testosterone to DHT.
PMID: 11307942 [PubMed - indexed for MEDLINE]

2

Hormone Specificity, Androgen Metabolism, and Social Behavior – REGAN 21 (1): 257 – American Zoologist

American Zoologist 1981 21(1):257-271; doi:10.1093/icb/21.1.257
© 1981 by The Society for Integrative and Comparative Biology

Hormone Specificity, Androgen Metabolism, and Social Behavior1

ELIZABETH ADKINS REGAN2
Department of Psychology and Section of Neurobiology and Behavior Cornell University, Ithaca, New York 14853

SYNOPSIS. The ability of different sex hormones to activate social signals can provide important clues to the biochemical mechanisms underlying these signals. A pattern of hormone specificity in which testosterone (T) and estradiol (E), but not dihydrotestosterone (DHT), are effective suggests that conversion (aromatization) of T to E in the brain may be involved or required; a pattern in which T and DHT, but not E, are effective suggests that conversion of T to DHT may be involved. The hormone specificity of social signals in diverse species of vertebrates is reviewed. Aromatization seems to be of widespread behavioral significance in mammals andbirds. A role for conversion of T to DHT is suggested for some signals. Aromatization of T mayalso be important for the activation of adult female behavior in mammals and lizards, and for the early organization of behavior in mammals and birds. Patterns of hormone specificity differ both across species for a given social signal, and within a given species when different signals are compared. An attempt is made to integrate these findings by relating patterns of hormone specificity to hormone levels, steroid receptor and enzyme concentrations and distributions, signal function and dimorphism, and phylogenetic status.

3

1: [Horm Behav.](javascript:AL_get(this, ‘jour’, ‘Horm Behav.’):wink: 1987 Sep;21(3):331-46.http://www.ncbi.nlm.nih.gov/entrez/query/egifs/http:–linkinghub.elsevier.com-ihub-images-PubMedLink.gif [Links](javascript:PopUpMenu2_Set(Menu3666686):wink:
Hormonal control of sexual and scent marking behaviors of male gerbils in relation to the sexually dimorphic area of the hypothalamus.

  • Yahr P ("Yahr P"[Author] - Search Results - PubMed),
  • Stephens DR ("Stephens DR"[Author] - Search Results - PubMed).
    Department of Psychobiology, University of California, Irvine 92717.
    The sexual and scent marking behaviors of male gerbils are stimulated by testosterone (T) action in the preoptic area (POA) of the hypothalamus. The sexually dimorphic area (SDA) in the posterior POA, which also responds to T, is implicated in this process. This research studied the sensitivities of mating, marking, and the SDA to T metabolites and other steroids. Experiment 1 focused on mating. Male gerbils were implanted at castration with 2-mm Silastic capsules containing T, dihydrotestosterone (DHT), 19-nortestosterone (19-nor T), estradiol (E), or no hormone and were tested 3-7 weeks later. T, E, and 19-nor T maintained intromissions, but E-treated males rarely ejaculated. Controls and DHT-treated males stopped mounting. Experiment 2 compared the ability of these steroids to reinstate marking and mating using the same dose and a larger one (5 mm). Androstenedione, 19-hydroxytestosterone (19-OHT), and E plus DHT were studied as well. Volumes of the SDA and SDA pars compacta (SDApc) were also measured. Only T, 19-nor T, E, and E + DHT reinstated sexual behavior, but all steroids except 19-OHT stimulated marking. E and DHT synergized to elicit mating. For marking, they were no more effective together than alone. Steroid-treated males had larger SDAs than controls. Moreover, steroids that stimulated sexual activity produced larger SDAs than steroids that did not. SDA size correlated with copulatory rate, but not with copulatory efficiency. SDApc size correlated with copulatory efficiency, but not with copulatory rate. Like copulatory rate and efficiency, sizes of the SDA and SDApc did not correlate with each other.
    PMID: 3666686 [PubMed - indexed for MEDLINE]
4

I had a concern about synthetic pheromone use possibly stimulating androgen production in women and its connection to hair loss. Although termed “male pattern balding,” DHT is responsible for the same condition in women.

5

DHT is classified as a class 1 Anabolic steroid and is a felony to distribute. If you want to boost your DHT levels and see if it helps there is a Bodybuilding supplement at IMPACT NUTRITION that utilizes DHT and is perfectly legal to purchase, but say goodbye to your hairline. :open_mouth: