Heh! Might be a bit difficult to get that protocol past the ethics review, eh?
<smirk>
BTW, terrific thread. Thanks!
Diane
Actually, we could have used vaginal photoplethysmography to measure vaginal pulse amplitude (an acceptable measure of wetness). It’s somewhat invasive for the women, though it is ethically accepted. You just need to make the case that this is real research, and use female research assistants. Otherwise, I think more men would become intimately involved in study design and execution.
Thank you, I’m enjoying this, too.
James V. Kohl
Sorry for the delay in responce, been very busy of late. Wetness responce is an interesting measurement, for the males would it be extended blood flow volume or speed of erection time?
But seriously, I was thinking about possible neurochemical interactions in the gaba system as related to none use. If gaba is released, it has a number of different biochemical pathways to possibly explain different reactions in people. What if the gaba is converted to ghb. Would that take into account the posts I have seen about people falling asleep or getting tired after exposure?
Also, if gaba release metabolizes into succinic seminaldehyde, could this cause negative feed back loop to glutamic acid and therefore increase production of the excitatory amino acid neurotransmitter glutamine in the hippocampus? If this is one possible responce then could that cause a “cuddle” responce in the person, or increased sensory need to touch and be touched? (Pdd, autistics and ausbergeres both show glutamine deficiencey and sensory problems).
In addition could the irratative responce be related to the backup of the figlu pathway causing increase in the shift from Histidine to Histamine? Histamine would increase irratation as well as counter fire adrenaline leading to slight annoyance or increased excitation. (depending on pre levels of neurotransmitter/ neurohormonal levels.)
I was also thinking that since carnosine (produced from histidine) is the major smell neurotransmitter in the cribafom plate and olfactory bulb, would a shift from glutamate to histidine (negative feedback loop) increase the sense of smell causing that deep nostril flaring responce I have seen several times?
Maybe the prefered biochemistry pathways in each individual causes the neurochemical shift and produces the responce based on the chemical levels before exposure. If this is the case then the chemical pattern of the individual is just as important as the psychological makeup. What do you think?
I’m only familiar with a few of the neurochemical interactions and some of the pathways you mention. At some point the focus must turn to what’s being effected by chemical signals from the social environment, which I’m rather certain is the gonadotropin releasing hormone (GnRH) pulse.
I recently returned from Neuroscience 2008 where there were 14,000 poster presentations. Several of the ones I looked at had to do with factors involved with GnRH pulse generation and frequency (e.g., kisspeptin). Our poster was relatively straightforward. A mixture of androsterone/androstenol changed some flirtatious behaviors in women and also their self reported level of attraction to our male accomplice during a 15 minute interaction. Our data supports extension of my mammalian model (Kohl, 2006) to women.
I think that individual chemical patterns underlie psychological make up, and that the most important of these chemical patterns are those that lead to sexual reproduction. These patterns are most likely ‘conditioned’ with exposure to the pheromones of others, and our response to other exposure-related sensory input from the social environment gets conditioned along the way.
James V. Kohl
Hello,
I have been observing a reaction from many women of late when I am sitting in a smaller closed room or car. Some of the women, maybe 60% show signs of allergic like responce. Redening of the eyes, sneezing, slight coughing. They also seem to respond well to the nones I am wearing.(These reactions occur after about 1 to 3 hours of useage so I don’t think it is over dose related.) They play with hair more, show more focused interest in what I am talking about and have pupil dilations. My though is along the lines of cribiform plate and carnosine activity. Since carnosine is a methyl derivative of Histidine and that also includes the histamine pathway could the nones be activating this system as well. Is the dose or type related not only to the other parts of the system (TAAR and such) but also sense of smell organ like the cribiform plate and olfactory bulb. (GABA and Glutamic acid are in a negative feedback loop with Histidine linking the entire systems together).
To extrapalate a little further, everyone knows about the so called “spring fever”. The time that mating signs kick in for most species. This is also the growing time for plants (pollen) and such. What if the increase sexual activity of humans is also related to the level of histamine released in the system. If it is a small amount(Histamine), then H3 and H4 receptors would kick in through out the brain and cause an increase in the releasing factors for the hormone systems. That would via the carnosine levels link the smell of nones and the increased sexual activity. It would also explain the overdoseing of nones causing irritation and down right hostility. Now I am not postulating that this is the whole mechanism here, but it may very well be another piece to a complex reaction.
I was reading an article on nones and attraction that matched the nones women found attractive to immunilogical compatability. The ones that the women were attracted to were also ones that added an immunilogical component they did not have. Thus expanding the offsprings possible immunity to a larger percentage of potential diseases. Because histamine is an immune chemical it would further support the possible connection.
It is interesting to see that this science of nones and their use as noverbal communication and genetic modulation is very vast and under examined.