It varies with individuals, but most people experience progressively reduced self-effects with regular use. I rarely feel a damn thing even if I soak myself in mones. My brain has learned self-effects are a false alarm and it doesn’t react. I think of it as a filtering effect: 1) brain detects mones and runs the data through a matrix; 2) brain checks for hot woman; 3) if hot woman is present it issues a red alert (dick get hard, etc.); or 4) no hot woman and the body is told to stand down.
On the other hand, mones on an attractive woman make me even more excited so context is everything. Realize mones evolved over millions of years as a form of communication between individuals, not as a form of self pollination or chemical masturbation.
There are things you can do to prolong the self effects like rotating products and taking breaks but eventually you become accustomed to the feeling and dont notice it.
Its kinda like caffeine. When you first experience caffeine its like..Whew this is great.. It peps you up and makes you all alert but after your body adjust to drinking it you dont notice a thing.