This report had one of the highest (certainly not the highest, but 200 is pretty high) reports for P83. No adverse affects, apparently. I found anything over 50 to be OD. Made me sleepy. I didn’t see any obvious benefit with 62.5 vs. 3 sprays of 12.5 mcg. More sprays just seemed a waste. What can I say. The science juggernaut I guess sometimes cannot be stopped. Good luck Dr. Jekyl. Look out for Mr. Hyde!