personally, i find p83 doseage a bit tricky…15mcg total [1 12.5mcg to go and quarter spray residue of a to go] was all i could handle before OD’iing…it seems arousing from 10 mcg’s upwards to 25mcgs, but my body chemistry only allows for the lower spectrums. its an erratic putative with little margin for dosing error. so, for me atleast, 45mcg’s would be futile and make people around me act agressively towards me.