A large family of vomeronasal receptors recognizes pheromone cues in many animals including most amphibia, reptiles, rhodents, and other mammals. Humans possess five vomeronasal-type 1 receptor genes (VN1R1-VN1R5), which code for proteins that are functional in recombinant expression systems. We used two different recombinant expression systems and identified Hedione as a ligand for the putative human pheromone receptor VN1R1 expressed in the human olfactory mucosa. Following the ligand identification, we employed functional magnetic resonance imaging (fMRI) in healthy volunteers to characterize the in vivo action of the VN1R1 ligand Hedione. In comparison to a common floral odor (phenylethyl alcohol), Hedione exhibited significantly enhanced activation in limbic areas (amygdala, hippocampus) and elicited a sex-differentiated response in a hypothalamic region that is associated with hormonal release. Utilizing a novel combination of methods, our results indicate that the putative human pheromone receptor VN1R1 is involved in extra-olfactory neuronal activations induced by the odorous substance Hedione. The activation of VN1R1 might play a role in gender-specific modulation of hormonal secretion in humans.
Great post. My only question is: what is exactly is it? Is it currently in some of the putatives offered by Androtics, would it be a putative by itself, or is it something currently unavailable/not offered?
I can vouche for this one.
When I added Hedione to my mixes it did many things, like caused women to dihl with me longer and harder and more often, and most notably it seemed to cause my significant other to never want to leave me side. After sex, she’d just lay there often falling asleep, even while she had to be somewhere, often times being very late. This was significant because she never did this before I added Hedione to my pheromone mix.
One other thing is it caused her to talk a lot about past experiences.
I read somewhere that Hedione does increase activity in areas of the brain associated with memory.
Nowadays, I see pheromone mixes infantile when they are not used with Hedione.
I concur with Jdub and find a 30% mix to be most ideal. I thought Hedione was used in sex mixes mainly and so that is where most of my testing with it is. I used with Ammo and tried going out during the day with it and I had great luck with it. I need to test more for day use but this thing looks promising. I can’t smell the hedione but I do know this thing is highly diffusive and think this is a part of the reason it works so well. I notice when I wear with other pheros it seems to help them diffuse nicely. I need to test more when I get to it, but I suggest any serious enthusiast to get for sure for your collection. It was actually Jbubs journal that convinced me to get some.