We know they have the power to influence the brain…but are they bad for the wearer’s brain/the people it affects?
Thanks dudes.
t_a_s
You realise that you are a walking phero factory right? Your body produces phero’s…they are natural compounds 
The worst that can happen with heavy dosing is neurotransmitter depletion, (much like what too much caffeine will do…overstimulation followed by “crashing”) but you can easily replenish as your body continously produces neurotransmitters. Keep well hydrated, eat a balanced diet & if you feel lite it add a multivitamin & some extra B Vit’s
Thank you Lord for showers! I’m sure our European forefathers all died horrid deaths due to mone overload after neglecting to bathe for a year or two. Also explains why the average life expectancy was so short prior to modern plumbing: poor suckers all OD after smelling their own mone infested pits.
Your body not only produces pheromones but it is also designed to recieve pheromone signals, so as with anything, used correctly they are perfectly safe.
Think of it as being similar to taste, tasting something isn’t exactly dangerous the substance you taste might not be good for you, but the actual tasting, i.e. the simulation of your taste receptors shouldnt have any adverse effects..
Also drinking too much water can kill you, and water is an essential product for life.
Only A1 can cause depression in a small number of men that I’m aware of otherwise there appears to be no other ‘issues’ with any other pheromone. Infact, I believe the medical industry have been using /testing pheromones to treat /aid people so I think overall they are a rather positive substance.
But in all fairness, these are synthetic pheromones and I don’t think we should stick them in the samed category. There could be unnatural side effect. Think about all the unnatural sugars out there, and how much worse they are compared to naturals… I’m not saying they aren’t safe, btw. I know I plan on ordering more regardless until someone proves without a shadow of a doubt that it effects one’s health. The only way to know for certain is to do blood work before/after regular dosing. I think they are probably safer than most the colognes/perfumes out there. Just google some of the ingrdients from your favorite scent and you will see what I mean. Good Luck.
Natural sugars and artificial sugars are not bio identical, they are molecularly different. Synthetic pheromones possess the identical molecular structure as secreted pheromones. Your body has no way of knowing the difference.
Many people have had blood work before after and during use and there is really no change. Of course the blood work was done for other reasons so perhaps they were not looking for a specific change. Regardless very little if any absorbs past the epidermis and into the blood. We also have a blood brain barrier which prevents it from entering through that pathway so unless you bathe in the stuff its not going to show in your blood. Even if it did it would not be recognized as something artificial or foreign in the blood because most pheromones are molecularly identical.
I do agree that more danger lies in the use of perfumes and colognes. These are not identical to anything found in the human body.
But to the original posters question (despite it being 3 years old) is… No they do not harm the brain. Your brain recognizes them the same as the “real” pheromones secreted by the person standing next to you who is subtlety and unconsciously sending signals . The only difference with synthetic is now your conscious and have more control over the signal your sending.
Tisha
[quote=“tisha23”]
Natural sugars and artificial sugars are not bio identical, they are molecularly different. Synthetic pheromones possess the identical molecular structure as secreted pheromones. Your body has no way of knowing the difference.
I stand corrected!
“We also have a blood brain barrier which prevents it from entering through that pathway so unless you bathe in the stuff its not going to show in your blood.”
'Nuff said! Thanks Tisha, you gave me the answer to a question i have been wondering lately myself..
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As mentioned, scents and impurities are probably a greater issue in pheromone use than the pheromones themselves.
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It is possible to get adverse reactions to pheromones, since people expose parts of their bodies to 10x or 100x the levels that those parts would normally be exposed to. For example, DHEAS applied to the skin in doses close to 100mcg can give some people acne so that should be avoided. That much DHEAS is more than most people have in their whole body, and it’s being applied to a small patch of skin. Some natural mones like neno sulfate (not used in any mixes that I’m aware of, but it does have pheromonal effects) seem to be irritants in high enough doses. Particularly susceptible individuals can have issues with certain naturally occurring androgens. For example, I had one acquaintance with hormonally dependent cancer which triggered when she went through puberty and a relative who had to go on androgen-suppressive drugs for his prostate cancer. That’s probably the minority case, however, but it demonstrates that even normal levels of androstanes can be dangerous in susceptible individuals.
For reference; normal serum testosterone level is around 80 ng/dl in women. AFPA Articles and Newsletters DHEA (dehydroepiandrosterone)
1 nanogram = 0.001 micrograms
How much blood is in the human body
men have 4-5 liters of blood or 40-50 deciliters.
So a woman has roughly 4mcg of testosterone in their whole body
An average man with high-normal DHEA levels may have as much as 81 mcg of DHEA in his blood, (DHEA is probably the most plentiful hormones which is also a pheromone. )
Normal DHEA levels
Males: 61-1636 ng/dL
Females: 102-1185 ng/dL
Dehydroepiandrosterone (DHEA), Serum
Age 18 – 50 years: 36 - 192 ng/dl ( total 9.6 mcg in the whole body for a normal adult man at the high end of the range)
http://toxwiki.wikispaces.com/DHEA_DHEAS
- Location/concentration of chemical exposure is as important as amount. There’s very good evidence for some level of mucosal absorption of pheromones in boars, whereby the mones avoid the blood brain barrier as well as first pass metabolism by the liver. The result is that very small quantities of molecule may potentially have disproportionately large impacts on the brain or skin.
Humoral pathway for transfer of the boar pher… [Theriogenology. 1999] - PubMed - NCBI
Many androstanes readily permeate the blood brain barrier
Long story short; the dose makes the poison. You can put someone in a coma with enough insulin, even though the stuff is entirely “natural” and endogenous to the body. So treat all chemicals with a reasonable amount of respect.
I personally only apply mones to clothes just to be careful. I seem to be more chemically sensitive than most individuals, partly due to living in a moldy house for several years. You may get a bit less diffusion, but they certainly do still work. I find it helps to wear long sleeves and apply them to the wrists to increase range. Putting your hands towards the person you’re talking to is not only helpful with diffusing in the right direction but it’s also a good posture if you’re not wearing mones.
If I’ve messed up my math, someone please correct me.
Helsinki Committee for Human Rights has recognized pheromones as both safe and ethical to use. They wouldn’t have made such a statement about something that is untested for health risks.
Good goddess I couldnt sleep so I came down to check my mail and noticed lots of panicked emails. Instead of replying to each I will just post here for those misunderstanding Lobos points.
What Lobos stated is correct however it doesn’t apply to pheromone as we use them.
Androgens in you and androgens on you are two different things. He is referring to androgen drugs or natural androgens inside the body. Not pheromones which (when used correctly) do not enter the blood system. I agree hormones can be dangerous to susceptible people when ingested or injected. Hormones and pheromones are related but do not travel the same pathways or have the same functions.
I want to point out Lobo mentioned “mucosal absorption of pheromones”
In this study anol was directly injected into the nasal passage. This study is not an indication of how airborne pheromones work nor does it point out any large impact on the skin. I strongly advise not spraying them in your eyes or nose or injecting them. We have often warned against spraying to the more delicate membranes for obvious reasons. Avoid pits and groin, membranes are thin in these areas. I think it was obvious not to spray it up your nose or in your eyes.
Its not enough to just look at these studies. You need to understand how the study is conducted, the methods used and how they relate to how we use pheromones so be sure to not just look at the conclusion when reading studies but the methods.
There are some androstanes that cross the blood brain barrier. However they need to be in your blood to cross. Your not ingesting or injecting your pheromones so whats in your blood is natural.
Here this may make it easier for some of our members to understand the BBB and its function. I know its for kids but its in plain english which helps people new to this or who are not science majors.
Neuroscience For Kids - blood brain barrier
It blocks substances from passing INTO the brain from the blood and that is what we refer to when we speak about it in conjunction with pheromones for those worried they may absorb some through the skin. Its not proven that these androgens are passed though the epidermis when used as we use sprays Like I said though sitting in a tub of it for a while and yes of course its going to pass through but in the quantity we use on the skin very little if any passes through and what may pass is metabolised by the liver.
As for the brain…
When people think of pheromones entering the brain they think of all of what they just sprayed on them flooding the brain. Not the case. Generally in here we just give you the short version without a lot of scientific jargon and details. The mones dont actually enter the brain so you dont have a bunch of mone molecules floating around up there.
They connect with the olfactory resceptors causing an electrical charge of sorts which transmites to the brain to trigger the neurotransmitters to signal between cells thus evoking emotions. Emotion is directly realted to attraction. How something makes us feel is what makes us respond to it with certain behavoirs.
So when we say “they enter the brain and trigger neurotransmitters” we dont mean the mone chemicals are floating around looking for recptors in the brain. Its an electrical charge.
Neuroscience For Kids - The Nose Knows
Pheromones while related to hormones work very very differently outside the body then they do inside the body. Do not confuse the two.
Now if your nervous about using them on your skin I agree with Lobo, by all means spray it on your clothes. I have used both methods over the last 20 years and I will say the reaction is more subtle with cloth applications but it does work to some extent. You have to use the method your most comfortable with.
I will also mention that I have used mones a long long time and have had many hormone panels done by my functional med practitioner as is a yearly practice of FMP’s. I cant remember if every time I used mones the same day but I would say at least half those times I have. My hormone levels have always been within normal range and I am a heavy pheromone user. Now this is just my experience so take it for what its worth.
Excellent post as usual, Tisha! Enjoyed the Kiddie links. 
Layman’s english explainer of a complex science topic.
Now, I would ask, then, you’ve been using mones since you were 10?!?!
Tisha = Brain and beauty… what a combo!!! 
1Alpha
Well well well, who’s the popular one? I didn’t get ANY panicked emails. Zip. Zilch. Nada. Not even a slightly worried private message. I must not be using the right mones… would alpha androstenol or beta androstenol be better for panicked emails… You know, it must be the copulins. I never use those. Maybe people weren’t really scared. They just wanted some Tisha-attention. 1Alpha does, anyways… 
Okay, I lied. Actually I did get a few worried private messages, but they had nothing to do with this post or pheromones in general. Next time I’ll be certain to call when I’m running late after work. Pinky swear.
Most androgens are small enough to absorb through skin, to some extent, provided the skin’s natural barriers are first weakend. You won’t get a lot in your blood that way. Skin irritation is certainly a problem with particular molecules for some people, just like some people can handle copper in their blood but not copper jewelry on their skin. Some of the fixatives and emulsifiers used in perfumes and colognes can weaken the skin’s barriers making people more susceptible. To be clear, I’m not saying that pheromone application on skin has been shown to cause any serious problems whatsoever. Just that it’s hard to prove a negative. They used warfarin medically for over 50 years before they began to understand its potential for promoting arterial calcification.
And some people are sick in a way that even their normal levels of hormones are problematic so it’s worth it for people to consider their own particular case, and whether they may be unusually susceptible. As you mentioned.
Yes, I’m paranoid. But that’s not always a bad thing.
Regarding mucosal absorption of pheromones;
It’s absolutely correct that huge quantities were used in the posted boar study, and applied directly to the nasal mucosa rather than inhaled. Microgram quantities like we use pheromonally would have been harder to measure and detect by the researchers, so they used abnormally large amounts. It’s up for debate to what extent that large dosage biased the results, but the researchers were interested in androstenol as a pheromone, just as we are. Applying the stuff to the nasal mucosa was a way to simplify the study design. Direct application and use of abnormally large quantities allow for a more accurate determination of the rate of permeability through the nasal mucosa, especially since decapitated boar heads don’t do much breathing. But a person smelling pheromones will only be exposed to absolutely minute (fractions of a microgram) quantities of pheromone.
I don’t know what kind of absorption they’d have gotten with microgram quantities in the air. Maybe the mucosa would absorb everything and degrade it. Maybe not. It’s a very open question, and I provided evidence for only one side of the debate.
Agreed, there would be significant metabolism by the liver for anything that made its way into the blood via the skin. The body is very well designed to metabolize and regulate these kinds of molecules in healthy individuals. (It’s worth noting that anything absorbed through the nasal mucosa would avoid first-pass metabolism via the liver. )
As for whether pheromones enter the brain; there’s still a lot of debate about how pheromones actually work. Generally, they’re considered to be handled by a different process than olfaction (smell.) For whatever reason, I’m anosmic to pheromones. I can’t smell a single one of them, and can walk into a room stinking like cat piss (I infer) and not be aware of it till a sea of people recede before me (and seem to remember it the next time they see me, based on their body language and avoidance.) Yes, I use cover scents (most of the time.) This insensitivity may be because I’m male, because I have a defective OR7D4 receptor, or because I degraded my sense of smell while working in the chem lab. But not smelling mones is fairly common. And I still react strongly to their social effects, despite being unable to smell them.
Some have argued for a human VMO, analogous to animals in the detection of pheromones. Vomeronasal organ
Some have argued for the importance of nerve zero in detection of pheromones. Cranial nerve zero
And there’s some evidence, like that posted previously, for minute amounts of direct absorption via the nasal mucosa. Just a few nanograms of material would be involved, almost nothing at all, but applied to sensitive enough biological equipment and amplified, it could make a difference.
Pregnenolone blocks GABA receptors in vivo, and I used this to predict that it would diminish parts of the effect of alpha androstenol pheromonally, since alpha androstenol has, in part, a GABAergic mechanism.
The receptors that pheromones use and the ones that hormones use endogenously seem to be related in some way.
That’s good to know. Thanks Tisha.
I am going to pretend I am not empathic right now (snort)
Hmm… no anol or bnol wont do it nor will copulins. Try some A314. People tend to go to the people they trust and feel comfortable with or the leaders in a group for advice when they are worried or upset. Activating your V-card in your user CP may help to.
I dont think your paranoid. I would call it cautious. Nothing wrong with that. Thank you for your additional explanation. I already understood where you were coming from and agreed with you so I didnt need it but I am sure it will be of interest to other members.
Tisha
Oops…yesterday I applied a lot of pheromone (Scent of Ero from luvessential) to my forehead…later my forehead was dirty and I washed it and I re-apply a lot. Maybe the water from the wash may have gone to my eyes or some of the pheromone may just have ran down to my eyes. Would it have gone to my eyes and will cause problem/health problem?
Can Logos and Tisha reply? thanks
Oh, great to hear that such a committee even says that they are ethical to use. I would’ve thought they were in a little bit of a gray zone in their eyes, as some of the mones are very, very powerful.
Short answer;
I’m not aware of any reason that the pheromone portion of your mix would directly cause any eye problems, especially from a single accidental exposure. I’m not sure about any perfumes that were added to your mix, though. Perfume can contain a whole host of chemicals.
Long answer;
I’m not sure if whatever cologne/cover scent you used could cause irritation for your eyes. I’d probably focus on that, rather than the mones.
Rinse your eyes and if they’re fine afterwards then you’re fine.
Also, mones are consumed by bacteria, particularly Corynebacterium bacteria. Generally speaking, these things are harmless or helpful, like eating yogurt, and slow growing. Outside of occasional smell, they shouldn’t be an issue. But if you had an issue with acne or some other pre-existing skin pathology, it’s possible that mones could exacerbate it by providing food for those bacteria (the bacteria could eat the mones or eat the extra sebum your skin produced because of the mones.) Those bacteria are not things I’d want in my eyes, but the mones themselves aren’t any more dangerous in this regard than rubbing very very small amounts of oil on your skin.
I haven’t been able to get good data on what the impurities in mones are. Androtics (Jasmin) claims to have pharmaceutical grade mones, but I’ve never personally seen any certificates of analysis from any supplier.
So I’m not aware, offhand, why a little bit of the stuff in your eyes would be an issue. You really should be fine. But if someone were going to dig deeper in terms of research, those are some areas I’d look.
I often scratch my skin because I have hives. Quite often my skin is wound from the scratching. Can I still apply pheromone on that area?
Personally, I’d avoid it just to be cautious. For the reasons previously mentioned.
Most people do not have their whole body skin intact…there may be some broken skin due to pimple, scratching, mosquite bite, etc for some reason…so must we avoid pheromone just because there is small broken skin here and there?
Do not spray on an open wound. even if you have a few cuts or scraps your whole body is not going to be covered with them and if it is pheromones should be your last concern. Just spray on a section of the body that doesnt have an open wound.
Its not going to kill you if you accidently get some on a cut. The alcohol will actually clean it but it will sting like hell and irritate it.
Tisha