Some of the molecules in his and other companies’ products are suspected neurosteroids, like THDOC. They are also suspected pheromones. Their mechanism is unknown. They may act by allosteric modulation of neurotransmitters, affecting mood by unknown paths in the central nervous system. Thus, P75, P102, TAF, etc. can cause neurotransmitter depletion, headache, agitation, insomnia, etc. in certain persons. They may alter endocrine feedback loops, shifting homeostatic balance. This is why females are highly prone to eating disorders but men are not. It is wildly more complex than I can begin to state here. The blood-brain barrier isn’t necessarily a factor as much as alteration of CNS function by unknown means. Hormone levels could (it depends) be altered by “pushing” endocrine feedback loops in a certain direction. We can’t cure eating disorders, etc., because we just don’t know how it works.
The prenatal migration of GnRH neurosecretory neurons allow human pheromones to effect GnRH pulsatility, which modulates the concurrent maturation of the neuroendocrine, reproductive, and central nervous systems, thus influencing the development of human reproductive sexual behavior and other behavior.